A TRANSCRIPTIONAL EVALUATION OF THE MELANOMA AND SQUAMOUS CELL CARCINOMA TIL COMPARTMENT REVEALS AN UNEXPECTED SPECTRUM OF EXHAUSTED AND FUNCTIONAL T CELLS

IntroductionSignificant heterogeneity exists within the tumor-infiltrating CD8 T cell population, and exhausted T cells harbor a subpopulation that may be replicating and may retain signatures of activation, with potential functional consequences in tumor progression.Dysfunctional immunity itsmajorlook.com in the tumor microenvironment is associate

BACKGROUND: To investigate the WM microstructure deficits in heroin dependent individuals (HDIs) with different length of heroin dependence, and to investigate whether these WM deficits can be related to the duration of heroin use and to decision-making deficits in HDIs.METHODOLOGY/PRINCIPAL FINDINGS: Thirty-six HDIs [including eighteen sHDIs (dura

Background and Objectives: Urine insulin-like growth factor-binding protein 7 (IGFBP-7), tissue inhibitor of matrix metalloproteinase 2 (TIMP-2), and neutrophil gelatinase-associated lipocalin (NGAL) monomer are novel tubular kidney injury biomarkers.In multiple myeloma (MM), immunoglobulin free light chains (FLCs) play an integral role in renal im

Video visual relation detection, which aims to detect the visual relations between objects in the form of relation triplet <subject, predicate, object> (e.g., “person-ride-bike”, “dog-toward-car”, etc.), is a significant and fundamental task in computer vision.However, most of the existing works about visua